Bone Morphogenetic Proteins: Building Blocks for the Periodontium
Ameet Mani, Ankita Dalvi, Shubhangi Mani, Shivani Sachdeva, Raju Anarthe
Bone morphogenetic proteins (BMPs) are a group of regulatory glycoproteins that are members of the transforming growth factor beta superfamily, which play key roles in bone and cartilage formation and various other biological processes, including limb, kidney, skin, hair, and neuronal development, as well as maintaining vascular homeostasis. They primarily stimulate differentiation of mesenchymal stem cells into chondroblasts and osteoblasts. Food and Drug Administration recently approved recombinant human BMPs (rh-BMPs) for accelerating bone repair and fusion and their potential as pharmacological agents for the treatment of slow-healing fractures and tissue fibrosis in patients. This may prove noteful in designing regenerative treatments in periodontics.
Glycoproteins, Growth factors, Periodontal regeneration, Periodontitis, Tissue engineering