Spectrum of Microbiological Infections in Acute Necrotizing Pancreatitis
Sadashiv Chaudharai, Rajeev Karvande, Pravin Shinde, Amar Kambale
BACKGROUND: Acute Necrotizing Pancreatitis (ANP) can have varied presentation from mild inflammation to widespread necrosis which can get secondarily infected. Infections complicating necrotizing pancreatitis are often polymicrobial and involve both aerobic and anaerobic bacteria as well fungi. In the present study, we are trying to find out spectrum of bacterial and fungal infections and their antimicrobial susceptibility METHODS: In this prospective observational study conducted over 18 months, we have studied 42 patients with ANP who have undergone intervention . cultures were obtained from the necrosum at the time of intervention. Obtained results were analysed. RESULTS: Out of 42 cases, 30 showed presence of bacterial infections and 6 showed presence of fungal infections. Gram negative Bacilli infections were predominant with maximum sensitivity to colistin. While Gram Positive Bacilli infections showed maximum sensitivity to Meropenem. Conclusion We conclude that Necrosis in Acute Pancreatitis frequently shows presence of bacterial and fungal infections. Gram Negative Bacilli is the most common Bacterial infections. Meropenem is the best empirical antibiotic for ANP.
Polymicrobial infection, antimicrobial susceptibility, Necrosum, Colistin, Meropenem.