Persistent MÃ¼llerian Duct Syndrome: Fertility Challenge
Hemraz Palawan, Sultan Al Thakafi, Serdar Coskun, Naif Al Hathal
Persistent MÃ¼llerian duct syndrome (PMDS) is a rare, autosomal recessive disorder of sex development, of male pseudohermaphroditism, characterized by the persistence of MÃ¼llerian duct derivatives: uterus, fallopian tubes, and upper vagina. Mutations of the gene or the receptor of anti-MÃ¼llerian hormone (AMH) are responsible for clinical symptoms of PMDS, with subjects having a 46 XY karyotype and a male phenotype. We report the case of a 23-year-old male patient with bilateral undescended testes (UDT) and the surgical management as well as briefly the ethical principles behind the certain clinical decision. In conclusion, we suggest that such cases need a holistic approach with a multidisciplinary team as well as patient and health care professional education.
Anti-MÃ¼llerian hormone, Autonomy, Beneficence, Hormones, Persistent MÃ¼llerian duct syndrome, Surgical management, Undescended testis.