International Journal of Education and Research in Health Sciences
(Official Publication of Sai Amrut Educational and Medical Research Foundation, Aurangabad)

Vol.3, Issue 4 (2017)

Intravesical Bacillus Calmette–Guérin Therapy for Bladder Carcinoma causing Bilateral Ocular Inflammation

Saroj I Sahdev, Shraddha Sureka, Rohan Agashe


We report two cases of patients, who developed ocular inflammation following intravesical Bacillus Calmette–Guérin (BCG) therapy. This is the first report of such a complication from India. The first patient developed bilateral conjunctivitis and the other developed bilateral conjunctivitis, anterior uveitis, and asymmetric bilateral arthralgia. Both the patients were treated with topical steroid eye drops to which they responded well. The increasing use of intravesical BCG may increase the number of cases of BCG-induced adverse events. The incidence of immune-mediated side effects due to intravesical BCG is very low due to genetic predispositions, such as presence of certain human leukocyte antigen (HLA). The specific associations are not clear and need to be further evaluated. Patients must be warned about this rare, but serious complication. Prompt treatment with local steroids should be started.


Bacillus Calmette–Guérin therapy, Bladder carcinoma, Immunotherapy, Reiter syndrome.

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International Journal of Education and Research in Health Sciences

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