Study of Serum Endothelin-1 Variation in Sickle Cell Disease: A Systematic Review and Meta-analysis
Chandrakant G Kamble, Prashant Hisalkar, Shekhar B Padhyegurjar, Jagdish D Powar, Santosh E Bidwe, Bhausaheb V Jagadale
INTRODUCTION: Serum endothelin-1 (ET-1) has been observed in sickle cell disease (SCD). The biological mechanism of the synthesis of ET-1 remains unclear. The aim of the meta-analysis is to provide an overview of serum ET-1 level changes and to discuss the significance of ET-1 in SCD. MATERIALS AND METHODS: A systematic review and metaanalysis to determine ET-1 level changes during SCD were conducted under Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Without language restrictions, the articles were identified through BioMed, Embase, PubMedÂ® (US National Library of Medicine, USA), www.bloodjournal.org, PLoS ONE, Web of Science, LILACS (Latin American and Caribbean Health Sciences Literature), BIOSIS Previews, and Elsevier Properties S.A., USA. The web sites that were searched for this study had been published before March 31, 2017. The mean, standard deviation, and sample size of cases and controls were compared and considered for the meta-analysis. RESULTS: We identified 6 prospective studies out of 309 articles; these are suitable data for the inclusion criteria for this study, of the plasma ET-1 level in SCD. From the included articles, the mean, standard deviation, sample size of cases and controls were compared and calculated by Statistical Package for the Social Sciences (SPSS) software. In all study analyses, p < 0.005 was considered to be statistically significant, and the meta-analysis of the study was statistically significant. CONCLUSION: The meta-analysis of this study was able to conclude that the plasma ET-1 level in SCD was significantly elevated. This will be helpful to treat the patients and the data could be used for research purposes.
Endothelin-1, Meta-analysis, Sickle cell disease.